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Determining When Patients Hospitalized With Acute Heart Failure Can Be Safely Sent Home (The DECIDE Study)

Posted: May 29, 2009
Identifier: NCT00911703
Purpose: The purpose of this study is to determine if certain findings (blood tests, symptom
improvement, etc.) after acute heart failure treatment can identify a group of patients who
are safe for early hospital discharge.
Sponsors: National Heart, Lung, and Blood Institute (NHLBI)
Abbott Point-of-Care
Inovise Medical
Vanderbilt University
Provider: National Heart, Lung, and Blood Institute (NHLBI)
Contact: University of Cincinnati, Cincinnati, Ohio, United States
       Sean P. Collins, MD, MSc, sean.collins@uc.edu
Conditions: Acute Heart Failure
Eligibility: Genders Eligible for Study: Both
Minimum Age Requirement: 18 Years
Maximum Age Requirement: N/A
Inclusion
Criteria:  
• Fulfill the modified Framingham criteria
• Have baseline data available within 1 hour of initial ED therapy
• Have previously documented systolic dysfunction (ejection fraction less than 50%) by
echocardiogram
• Willing and able to give informed consent
Description:   A fundamental question faced by physicians treating acute decompensated heart failure (ADHF)
is "When has treatment worked sufficiently for safe discharge, and who requires further
treatment?" Patients with ADHF have a high incidence of morbidity and mortality. Current
guidelines for emergency department (ED) and hospital disposition of patients with ADHF are
based on limited empirical evidence. This creates clinical uncertainty regarding disposition
leads to prolonged hospitalizations, higher costs and increased resource consumption. The
specific aim of the study is to develop a prediction rule from readily available clinical
data to help physicians identify ADHF patients eligible for safe and early discharge from
the ED and hospital after treatment is initiated.

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