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CCTST Grand Rounds on Epigenetics and Disease Risk
Date: Friday, June 3, 2011
Time: 11 a.m. - 1 p.m.
Location: Medical Sciences Building Room 2351


The next Center for Clinical and Translational Science and Training (CCTST) Grand Rounds will focus on epigenetics, the study of heritable but potentially re­versible changes in gene function that do not involve changes in DNA sequence.
  • From 11 a.m. to noon, Shuk-mei Ho, PhD, will discuss, "Epigenetics and De­velopmental Origins of Complex Disease: New Prospects for Epidemiology Re­search." Ho is the Jacob A. Schmidlapp chair and UC professor of environmental health. She will discuss the current understanding of early-life re-programming of disease risk via epigenetic mechanisms; advance the theory that epigenetic marks created during critical windows of susceptibility interact with lat­er-life events to bring out variable and potentially reversible phenotypes; and explore the opportunities and challenges in translating basic science findings in this field to epidemiology and clinical research.
  • From noon to 1 p.m. Karin Michels, ScD, PhD will discuss, "How Does the Intrau­terine Life Shape Your Epigenetic Profile?" Michels is associate professor of epidemiology in the Harvard University School of Public Health. Her talk will explore how exposures that occur in utero influence DNA methylation, explain how DNA meth­ylation improves our ability to identify disease risk, and identify later health outcomes associated with modifications of the epigenome.
CCTST Grand Rounds, made possible by a National Institutes of Health Clinical and Translational Science Award (CTSA), are free of charge and open to the public. CME is available.

For more information:

Contact Susan Moore at

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