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Cardiovascular Center of Excellence: Deanís Distinguished Seminar Series
Date: Monday, June 13, 2011
Time: Noon - 1 p.m.
Location: Medical Sciences Building Room 3351

Description:

The Cardiovascular Center of Excellence will present the last seminar for the year in the Deanís Distinguished Seminar Series Monday, June 13. Jeffrey Towbin, MD, professor of pediatrics, will present "Final Common Pathways of Inherited Cardiomyopathies."
 
Presentation Abstract:
The cardiomyopathies are disorders of heart muscle that commonly present with heart failure or sudden death. These disorders have variable clinical and morphologic features. This variability has led to multiple forms of cardiomyopathy being classified, including dilated, hypertrophic, restrictive, arrhythmogenic, and noncompaction forms.

The genetic causes of these disorders are being clarified and the mechanisms are being uncovered. In this presentation, data will be provided that suggests that the clinical phenotype is dependent on the disruption of specific "final common pathways". That is, the phenotype is de[pendent on the gene mutated, the specific domain of the protein that is disturbed and the resultant disturbance of the mutation on the binding of partner proteins. In addition, the understanding of these mechanisms has the potential to facilitate targeted therapies and this will also be discussed.

For more information:

Contact Donna S. Gering at (513) 558-2307 or donna.gering@uc.edu



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