Biomarker discovery through nuclear magnetic resonance (NMR)-based metabonomics and gene expression profiling is the focus of the next Center for Clinical and Translational Science and Training (CCTST) Grand Rounds on Friday, October 14, in Cincinnati Children’s Research Auditorium, Location R, Room 3381.
From 11:00 a.m. to noon, Michael Kennedy, PhD, will present, "NMR-based metabonomics studies of human disease: biomarker discovery for clinical applications." Dr. Kennedy is an Ohio eminent scholar and professor in the department of chemistry and biochemistry at Miami University. He will describe how NMR spectroscopy can be used to discover disease biomarkers; techniques for statistical analysis and validation of biomarkers; and factors to consider in human and animal model studies to ensure sufficient statistical power.
From noon to 1 p.m., Hector Wong, MD, professor of pediatrics and director of critical care medicine at Cincinnati Children’s, will discuss, "Gene expression profiling in pediatric septic shock: biomarker and therapeutic target discovery." He will describe a national-level program focused in this area, demonstrating how expression profiling data are being translated to discovery of stratification and diagnostic biomarkers as well as to discovery of novel therapeutic targets.
CME is offered. Lunch is available to CCTST members, by RSVP only.