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Jonathan Bernstein, MD, is a leading researcher in asthma and allergies.  
Jonathan Bernstein, MD
Specialty: Internal Medicine
Sub-Specialty: Allergy/Asthma
Department: Internal Medicine, Immunology and Allergy
Title: Associate Professor
Phone: (513) 558-5533
Home Page:


MD: University of Cincinnati College of Medicine, 1985
BA (chemistry): Kenyon College, 1981
Fellowship: Allergy and Immunology, Northwestern University, 1988-1990
Residency: Internal Medicine, Cleveland Clinic Foundation, 1986-88
Internship: Internal Medicine, Cleveland Clinic Foundation, 1985-86
Certification: Board certified in internal medicine and allergy and immunology


Chronic rhinitis subtypes, asthma, environmental control of chronic rhinitis and asthma, indoor and outdoor air quality, occupational asthma, drug hypersensitivity, chronic urticaria, hereditary and idiopathic angioedema, chronic dermatitis/eczematous disorders.

Current Research:

Assessment of women with and without asthma exposed to cleaning agents in the home (Clinical Research Award in Women's Health; CHEST foundation)

A pilot study investigating the effect of omalizumab (xolair) in work-related animal induced asthma (physician investigator initiated study funded by Genentech)

Using A Validated Questionnaire To Identify Phenotypic Markers Of Patients With Chronic Rhintis (physician investigator initiated study funded by Medpoint pharmaceutical)

Can Olfactory Receptor Polymorphisms Be Used to Differentiate Clinical Phenotypes With and Without Tobacco Smoke Intolerance? (Philip Morris Extramural Funding)

Investigation of anti-inflammatory effects of telithromycin in asthma (physician investigator initiated study submitted to Sanofi-aventis)

Effect Of Switching Asthmatic Children To Nebulized Budesonide Respules, Currently Treated with Montelukast, On Exhaled Nitric Oxide (eNO) (physician initiated investigator study submitted to Astra-Zeneca)

A Double Blind, Randomized, Placebo Controlled Trial of the Effect of CREON2000 on diurnal Peak Expiratory Flow Rate variability (PEFRvar), and Forced Expiratory Volume in One Second (FEV1) in Individuals with Moderate Persistent Asthma

Professional Affiliation:

AAAAI EORD Interest Section (Secretary)
AAAAI Indoor Air Pollution Committee (Chairman)
AAAAI Occupational Lung Disease (Member)
ACAAI Drug and Anaphylaxis Committee (Chairman)
Veteranís Hospital Department of Research Committee
ACGIH Bioaerosol Committee

American Medical Association
American College of Physicians (Fellow)
American Academy of Allergy and Immunology (Fellow)
American College of Allergy and Immunology (Fellow)
American Thoracic Society/Ohio Thoracic Society
American College of Chest Physicians (Fellow)
American Association for the Advancement of Science 
American Federation of Clinical Reseach
American Association of Immunologists
Ohio Medical Association and Cincinnati Academy of Medicine
Ohio Allergy Society/Cincinnati Allergy Society

Recent Awards/Honors:

Cincinnati Business Courier Health Care Heroes "Innovator of the Year Award" (2003)
Cincinnati Magazine's "Top Doctor" (2000-2005)

Selected Publications:

Publications 2000 - current:
Yan L, Galinsky RE, Bernstein JA, Liggett SB, Weinshilboum RM.  Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.  Pharmacogenetics 10: 261-266; 2000.

Andrews RP, Burrell L, Rosa-Rosa L, Cunningham CM, Brzezinski JL, Bernstein JA, Khurana Hershey GK.  Analysis of the Ser786Pro Interleukin-4 Receptor Alpha Allelic Variant in Allergic and Non-allergic Asthma and its Functional Consequences.  J Allergy Clin Immunol 100: 298-304; 2001.

Hickmann MA, Nelson ED, Siegel EG, Bernstein JA. Are High-Dose Toxic Exposures Always Associated With Reactive Airways Dysfunction Syndrome (RADS)? Archives of Environmental Health 56: 439-442; 2001.

Trout D, Bernstein J, Martinez K, Bioaerosol Lung Damage in a Worker with Repeated Exposure to Fungi in a Water-Damaged Building.  Environ Health Persp 2001; 109:641-644.

Bernstein JA, Bernstein DI, Bernstein IL.  Allergenicity of Cry9C: An Unresolved Issue.  J Allergy Clin Immunol 108: 655-6; 2001.

Risma KA, Wang N, Andrews RP, Cunningham CM, Ericksen MB, Bernstein JA, Chakraborty R, Khurana Hershey GK. V75R576 IL-4 Receptor É— Is Associated With Allergic Asthma and Enhanced IL-4 Receptor Function. J Immunol 169:   1604-1610; 2002.

Bernstein JA, Bernstein IL.  A Novel Case of Mealworm-Induced Occupational Rhinitis in a School Teacher.  Allergy and Asthma Proceedings 23: 41-44; 2002.

Bernstein DI, Bernstein CK, Deng C, Murphy KJ, Bernstein IL, Bernstein JA, Shukla R.  Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study.  Ann Allergy Asthma Immunol 2002; 88:272-278.

Prenner BA, Bernstein JA.  Clinical Benefits of switching to an inhaled corticosteroid extrafine aerosol; a case series.  Eur Rev Med Pharmacol Sci 2002;6:61-65.

Bernstein JA.  ROSTRUM-Material Safety Data Sheets (MSDS): Are they reliable in identifying human hazards? J Allergy Clin Immunol 110; 35-38: 2002.

Bernstein JA.  Allergic Rhinitis and Asthma: The Role of Allergen Avoidance.  J Resp Diseases 23; 572-580: 2002.

Bernstein JA, Garramone SM, Lower EG.  Successful Treatment of Autoimmune Chronic Idiopathic Urticaria With Intravenous Cyclophosphamide.  Annals of Allergy, Asthma and Immunol 89; 212-214: 2002.

Bernstein DI, Bernstein CK, Deng C, Murphy KJ, Bernstein IL, Bernstein JA, Shukla R.  Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study.  Ann Allergy Asthma Immunol 2002; 88:272-278.

Bernstein JA.  ROSTRUM-Material Safety Data Sheets (MSDS): Are they reliable in identifying human hazards? 2002;110:35-8.

Darcey D, Lipscomb HJ, Epling C, Cherry LP, Bernstein J.  Clinical Findings for Residents near a Polyurethane Foam Manufacturing Plant.  Arch Env Health 2002; 57:239-246.

Seth K, Lincourt W, Merchant BSK, Edwards L, Grim C, Dorinsky P, Bernstein JA.  Patient Perceptions of an Inhaled Asthma Medication Administered as an Inhalation Powder via the Diskus or as an Inhalation Aerosol via a Metered Dose Inhaler.  Ann Allergy Asthma Immunol 2003;91:55-60.

Woo JG, Assa°¶ad A, Heizer AB, Bernstein JA, Khurana Hershey GK.  °V159 C->T Polymorphism of CD14 Is Associated with Non-Atopic Asthma and Food Allergy.  J Allergy Clin Immunol 112:438-444; 2003.

Bernstein JA, Perez A, Floyd R.  Is Burning Semen Syndrome a Variant Form of Seminal Plasma Hypersensitivity?  Obstetrics and Gynecology 2003; 101:93-102.

Bernstein JA. Genetic Association Studies: What are they teaching clinicians? J Allergy Clin Immunol J Allergy Clin Immunol 2003; 111: 465-66.

Bernstein JA, Bernstein IL, Bucchini L,  Clinical and Laboratory Investigation of Allergy to Genetically Modified Foods.  Environ Health Perspective 2003;111:1114-1121.

Bernstein JA. High Efficiency particle arrest vacuums and cat allergen exposure.  J Allergy Clin Immunol 2003; 112: 462.

Bagenstose S, Levin L, Bernstein JA. The Addition of Zafirlukast to Cetirizine Improves the Treatment of Chronic Urticaria in Patients with Autologous Serum Skin Test Results.  J Allergy Clin Immunol 2004; 113:134-140.

Bernstein JA, Alexis N, Barnes C,  Health Effects of Air Pollution.  J Allergy Asthma Clin Immunol 2004; 114: 116-1123.

Resnick DJ, Hatzis DC, Kanganis P, Liccardi FL, Lee-Wong M, Bernstein JA.  The Approach to Conception for Women with Seminal Plasma Protein Hypersensitivity.  AJRI 2004; 52:42-44.

Bernstein JA. Interfacing Computers and the Internet With Your Allergy Practice.  Clinical Reviews Allergy Immunol 2004; 27: 115-121.

Finkelman FD, Yang M, Orekhova T, Clyne E, Bernstein J, Whitekus M, Diaz-Sanchez D, Morris SC.  Diesel exhaust particles inhibit Interferon-gamma production by inhibiting cytokine effects on NK and NKT cells.  J Immunol 2004; 172:3808-13.

Kim KT, Kerwin E, Landwehr L, Bernstein J,  Safety and Efficacy of Ipratroprium Bromide Nasal Spray 0.06% in  Young Children 2-5 years of age with Rhinorrhea Associated with a Common Cold or Allergy.  Ann Allergy Asthma       Immunol 2005; 94:73-89.

Bobbitt RC, Crandall MS, Venkataraman A, Bernstein JA.  Characterization of a population presenting with suspected mold-related health effects.  Ann Allergy Asthma Immunol 2005; 94: 39-44.

Miller ME, Levin L, Bernstein JA.  Characterization of a Population of Monozygotic Twins with Asthma.  J Asthma 2005;42: 325-330.

Corren J, Storms W, Bernstein J, Effectiveness of Azelastine Nasal Spray Compared with Oral Cetirizine in Patients with Seasonal Allergic Rhinitis.  Clin Therap 2005;27: 1-12.

Finkelman FD, Yang M, Perskins C, Schleifer K, Sproles A, Santeliz J, Bernstein JA, Suppression Effect of IL-4 on IL-13-Induced Genes in Mouse Lung. J Immunol 2005;174:4630-4638.

Bernstein JA, Bobbitt RC, Levin L,  Health Effects Of Ultraviolet Irradiation In Asthmatic Children°¶s Homes.  J Asthma, May 2006.

Bernstein JA.  Rationale, Patient Selection and Socio-Economic Considerations for Allergen Immunotherapy. Practice Parameters: Monograph on Allergen Immunotherapy.  J Allergy Clin Immunol (in press).

Bernstein JA, Levin L, Crandall MS, Effective Reduction of Dew Point and Airborne Mold Spore Counts By Dehumidification With HEPA Filtration In Day Care Centers.  Indoor Air (in press).

Brandt D, Bernstein JA.  Questionnaire evaluation and risk factor identification for non-allergic rhinitis.  Ann Allergy Asthma Immunol (in press).




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keywords: Jonathan Bernstein, allergy, asthma, indoor air quality