More Ways to Connect
  LinkedIn Twitter YouTube Instagram

University of Cincinnati Academic Health Center
Publish Date: 01/21/99
Media Contact: AHC Public Relations, (513) 558-4553
PDF download
RSS feed
related news
share this
UC Researchers Seek Volunteers for Depression Treatment Study

Cincinnati—For the last decade, many people suffering from depression have been helped by a new generation of antidepressants called selective serotonin reuptake inhibitors (SSRI). The new antidepressants, such as Prozac, became popular because of their improved safety and tolerance over the older MAO inhibitors and tricyclic antidepressants.

However, a third of patients do not respond to SSRI medications, and some patients report disturbing sexual, neurological, or gastrointestinal side effects. Recent research suggests that substance P, a protein found in smooth muscle, peripheral nerves, and the central nervous system, is a neurotransmitter/modulator that may initiate mental distress.

Lesley Arnold, MD, assistant professor and principal investigator of the study in the Department of Psychiatry at the University of Cincinnati (UC) College of Medicine says, "UC researchers will test substance P inhibitors to see if they have an antidepressant effect."

Interested volunteers who have been diagnosed with major depression may find out if they qualify to participate in this study by calling Natalie at (513) 558-3249.

 back to list | back to top