CINCINNATI—Nobel laureate Phillip Sharp, PhD, will speak at
the University of Cincinnati (UC) and Cincinnati Children’s Hospital Medical
Center Nov. 7 and 8 and receive the President’s Award for Excellence from UC
President Santa Ono, PhD.
Sharp, president -elect of the American Association for the
Advancement of Science, will speak at 4 p.m. Thursday, Nov. 7, at Kresge
Auditorium in the Medical Sciences Building on UC’s medical campus. His topic
will be: "CONVERGENCE: Biomedical Science in the 21st Century.”
Before the talk, which is sponsored by the Fellows of the
Graduate School and the Office of the President, Ono will present Sharp with
the President’s Award for Excellence for his significant contributions in
research and education.
"Dr. Sharp is an icon in the field of molecular biology,”
Ono says. "What elevates him further in my eyes is his humble demeanor and his
service to others via a myriad of leadership positions.”
Sharp will present a second lecture at 10 a.m. Friday, Nov.
8, in the Cincinnati Children’s Research Auditorium (R3381) on "The Synthesis
and Function of Noncoding RNAs.” The talk is part of the Rachford Lecture
series, sponsored by the Cincinnati Children’s Research Foundation.
Both lectures are free and open to the public. They
represent a homecoming for Sharp, a native of Falmouth, Ky. Phillip Sharp
Middle School in his native Pendleton County was named in his honor.
Sharp is Institute Professor at the Massachusetts Institute
of Technology (MIT), where much of his research work has been conducted at the
Koch Institute for Integrative Cancer Research (formerly the Center for Cancer
Research), which he joined in 1974 and directed from 1985 to 1991. He
subsequently led the Department of Biology from 1991 to 1999 before assuming
the directorship of the McGovern Institute for Brain Research from 2000 to 2004.
Sharp’s research interests have centered on the molecular
biology of gene expression relevant to cancer and the mechanisms of RNA
splicing. His landmark achievement was the discovery in 1977 of RNA
splicing, an achievement that earned him the 1993 Nobel Prize in Physiology or Medicine. His lab has now turned its attention to understanding how RNA
molecules act as switches to turn genes on and off (RNA
Sharp is a graduate of Union College in Barbourville, Ky.,
and earned his PhD in chemistry from the University of Illinois,
Champaign-Urbana. He pursued postdoctoral training at the California Institute of
Technology, where he studied the
molecular biology of plasmids from bacteria. Prior to joining MIT, he was
senior scientist at Cold Spring Harbor Laboratory in Cold Spring Harbor, N.Y.