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University of Cincinnati Academic Health Center
Publish Date: 11/14/13
Media Contact: Keith Herrell, 513-558-4559
Jim Feuer, 513-636-4656
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Faculty Members Play Leading Role in Study on Safety of Teen Weight-Loss Surgery

Two UC College of Medicine faculty members played leading roles in the largest in-depth scientific study of its kind on the safety of teen weight-loss surgery.

The study, published online Nov. 4, 2013, in JAMA Pediatrics, was the first to provide much-needed safety data on bariatric surgery for adolescents with severe obesity, a growing health problem in the U.S. and abroad. Researchers reported few short-term complications for adolescents with severe obesity undergoing bariatric surgery.

The findings represent the largest-ever multicenter, prospective study on the safety of weight loss surgery among adolescents. Led by investigators at UC and Cincinnati Children’s Hospital Medical Center and funded by the National Institutes of Health (NIH), research was conducted at five sites around the country.

Thomas Inge, MD, PhD, the study’s principal investigator, is a professor of surgery at the College of Medicine and an attending surgeon and surgical director of Surgical Weight Loss Program for Teens at Cincinnati Children’s.

C. Ralph Buncher, ScD, professor emeritus of epidemiology and biostatistics in the UC Department of Environmental Health, is the principal investigator of the study’s Data Coordinating Center. In addition, Buncher has received a supplementary grant of $250,000 from the NIH to investigate how data from the study will be transmitted after publication to the NIH data archives and how to centralize study follow-up visits.

The study was conducted from 2007 to 2012 at sites in Houston, Columbus, Birmingham, Pittsburgh and Cincinnati and examined major and minor complications occurring within 30 days of weight loss surgery. It involved 242 participants with an average age of 17 and median body mass index of 50.5.  For reference, a 16-year-old girl of average height with a BMI of 50 has a weight of nearly 300 pounds.  All participants in the study suffered from health complications resulting from obesity. 

Laparoscopic gastric bypass surgery was performed on 66 percent of the study participants, while 28 percent underwent vertical sleeve gastrectomy and another six percent underwent adjustable gastric banding.  Information on complications was collected 30 days after surgery.

Initial data from the study suggests that weight loss surgery can be offered to adolescents with a reasonable expectation of short-term safety. Seventy-seven percent of study participants showed no post-procedure complications, and an additional 15 percent exhibited only minor complications, such as dehydration. Eight percent of the patients suffered major complications, such as reoperation.  There were no deaths.

"This is important news for families considering bariatric surgery for severely obese teens,” Inge says. "Parents who are considering weight loss surgery for their sons and daughters worry about complications and ask a lot about the safety of surgery—this study should help to alleviate or at least bring those concerns into context.” 

Inge and study colleagues say further research is necessary to accurately gauge long-term risks and benefits for adolescents undergoing weight loss surgery. The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) is currently following these participants to collect this information.  



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