More Ways to Connect
  LinkedIn Twitter YouTube Instagram
College of Medicine

College of Medicine
Back Next
Publish Date: 07/15/14
Media Contact: AHC Public Relations, (513) 558-4553
PDF download
RSS feed
related news
share this
Researchers Describe How Bacterium Irritates Gastric Tissue

CINCINNATI—New research from the University of Cincinnati (UC) describes how a bacterium known as Helicobacter pylori initially interacts with and irritates gastric tissue, promoting stomach ulcers and cancer.

In an article published Thursday, July 17, in the scientific journal PLOS Pathogens, a team of scientists led by  Marshall Montrose, PhD, describes how H. pylori rapidly identifies and colonizes sites of minor injuries in the stomach and almost immediately interferes with healing at those sites.

Montrose is chair of the UC College of Medicine’s Department of Molecular and Cellular Physiology and interim chair of the Department of Pharmacology and Cell Biophysics. On Aug. 1, he will become UC vice provost and dean of the Graduate School.

Smoking, alcohol, excessive salt intake and non-steroidal anti-inflammatory drugs cause damage to the tissue lining the stomach, and are associated with stomach ulcers. The UC scientists asked whether H. pylori can sense and respond to such damage and so contribute to disease development.

The researchers induced small stomach lesions in anesthetized mice and observed that H. pylori bacteria can rapidly detect the injury site and navigate toward it. Within minutes, accumulation of bacteria interferes with repair of the tissue damage—and these results are the earliest indication showing H. pylori causing disease.

To examine how the bacteria accomplish this, the researchers also studied mice with larger stomach lesions (ulcers) that were subsequently infected with H. pylori. They found that H. pylori preferentially colonizes stomach tissue at injured ulcer sites, and there impairs healing of the damaged tissue.

Selective colonization requires both bacterial motility and chemotaxis (the ability to change direction of movement in response to environmental cues), and higher levels of bacterial accumulation cause slower healing. However, when extremely high levels of immotile or chemotaxis-deficient bacteria are added to damaged tissue, they can also slow healing.

As the researchers explain, "it’s like a tag team race. Chemotactic machinery guides H. pylori into the damage site to colonize, and then other virulence factors take over to make sure the site stays just as tasty in the long term by slowing repair of any damage.”

While the signals that attract H. pylori (but not benign stomach bacteria) toward injured tissue are not yet known, the researchers hope that their ability to rapidly measure H. pylori accumulation at the injured site now provides an experimental setup to determine the factor(s) involved.

"The broader implications of our work,” the researchers say, "are that even subclinical insults to the stomach that occur in daily life (damage from grinding of food, ingestion of alcohol, taking an aspirin) can potentially attract H. pylori and not only slow repair of any existing damage but maybe also provide an initiation site that can start the pathogenic sequence of more severe stomach diseases caused by H. pylori.”

The team’s work was supported by National Institutes of Health grants RO1 DK54940. The authors report no competing interests.

 back to list | back to top