cancer is the fourth-leading cause of cancer-associated death, and pancreatic
ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer that
involves the tumor building a protective barrier around itself which makes it
harder to treat, accounts for over 80 percent of all forms of pancreatic
thanks to research funded by the GIVEHOPE Pancreatic Cancer Research and
Awareness Fund and BSI Engineering, Cincinnati Cancer Center and UC Cancer
Institute scientists hope to make it easier for patients and their doctors to
beat this disease.
$50,000 grant was awarded to a team led by Vladimir Bogdanov, PhD, assistant professor and
director of the Hemostasis Research Program within the division of hematology
oncology at the UC College of Medicine, to conduct research specifically
focused on using a novel form of Tissue Factor as a diagnostic and possibly a therapeutic
target for pancreatic cancer patients.
Tissue Factor—termed asTF—is a protein that promotes formation of functional
vascular networks, and tumor cells hijack this mechanism to fuel their growth
and spread,” says Bogdanov, who is also a member of the CCC and UC Cancer
Institute. "While the expression of this form of Tissue Factor has been detected
in several PDAC cell lines, and increased asTF activity can promote primary
tumor growth, the role of asTF in the metastatic spread of PDAC has only been
this funding, we hope to study the effects of asTF on the genes that are
involved in metastatic progression, with hopes of using our findings to create novel
diagnostic tools and therapeutic targets.”
stresses that this grant, which is his second award from GIVEHOPE and BSI—the
first was given in 2012—is necessary to continue his lab work in this area and
hopefully gain even more federal funding in the future.
first, smaller grant was instrumental for my lab in securing a larger, two-year
exploratory grant from the National Cancer Institute. When researchers are between
grants, the work must continue somehow,” he says. "These types of grants make
it possible. They can even be our lifelines, sometimes.
incredibly grateful to GIVEHOPE and BSI because their grant will help my lab
continue its research that will hopefully lead to the discovery of more
effective diagnostic and therapeutic approaches to fight PDAC.”