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University of Cincinnati Academic Health Center
Publish Date: 12/03/01
Media Contact: AHC Public Relations, (513) 558-4553
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NIH Funds Diabetes Phenotyping Center

Cincinnati, OH--Patrick Tso, PhD, University of Cincinnati (UC) professor of pathology and lab medicine and associate director of the Cincinnati Obesity Research Center, is the principal investigator of a $6 million, five-year award from the National Institutes of Health (NIH), to investigate and characterize various metabolic and physiological functions of genetically-engineered mice that are being targeted for diabetes research. UC is one of only four national centers funded by the National Institutes of Health to conduct this research. Childrenšs Hospital Medical Center in Cincinnati is involved in one component of the UC project. The other three centers are located at Vanderbilt University in Nashville, Yale University in New Haven, and the University of Texas Southwest in Dallas.

According to Tso, a group of scientists at the UC Medical Center are establishing the NIH-funded Center to provide phenotyping services on animals that have had specific genes modified to investigate the role of these genes in the etiology and complications associated with having diabetes. Six different cores are included in the center:
1) administrative/statistical;
2) animal care;
3) lipid, lipoprotein, and glucose metabolism;
4) cardiovascular and renal function;
5) food intake, energy metabolism, and body weight regulation; and
6) immunology and islet transplantation.

"The establishment of this center certainly impacts profoundly on the diabetes and obesity research currently being conducted on campus," Tso said. "We are now in a position to attract first-rate scientists working on diabetes, and our researchers will have great opportunities to collaborate with world-class scientists to gain a better understanding of the etiology, cure, and prevention of diabetes. Additionally, the funding of this center will have a positive impact on UC as well as the city. We are very grateful for the support of NIH and the UC College of Medicine, particularly Dean John Hutton, MD, and Senior VP Donald Harrison, MD," Tso added.

Researchers from the UC College of Medicine who will have a major role in the operation of the new center include:

  • David D'Alessio, MD, associate professor of endocrinology in internal medicine;
  • Sean Davidson, PhD, assistant professor of pathology and lab medicine;
  • Ingrid Grupp, MD, professor of pharmacology and cellular biophysics;
  • Philip Howles, PhD, research assistant professor of pathology and lab medicine;
  • David Hui, PhD, professor of pathology and lab medicine and vice chair of research at the UC Medical Center;
  • Jonathan Katz, PhD, associate professor of pediatric endocrinology and director of diabetes research for the Childrenšs Hospital Medical Center;
  • John Lorenz, PhD, assistant professor of molecular and cellular physiology;
  • Jo El Schultz, PhD, assistant professor of pharmacology and cellular biophysics;
  • Randy Seeley, PhD, associate professor of psychiatry and associate director of the Cincinnati Obesity Research Center;
  • Stephen Woods, PhD, professor of psychiatry and director of the Cincinnati Obesity Research Center; and
  • Laura Woollett, PhD, associate professor of Pathology and Lab Medicine.

 



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