Cincinnati—On January 1, 1999, researchers at the University of
Cincinnati (UC) College of Medicine will begin phase 2 of a study of
all patients diagnosed with stroke at 18 hospitals located in the
Greater Cincinnati and Northern Kentucky area. Led by principal
investigator Joseph Broderick, MD, UC professor of neurology, the
Greater Cincinnati/Northern Kentucky stroke team will identify all
cases of stroke. They also will document the three-month outcome and
obtain blood from 500 of these patients in an attempt to identify genes
that may predispose one to stroke.
The study, entitled "A Comparison of Hemorrhagic and Ischemic Stroke
Among Blacks and Whites," is funded by a $2.3 million grant from the
National Institute of Neurological Disorders and Stroke (NINDS). The
NINDS is part of the National Institutes of Health. The goal of this
study is to document the number of people who have strokes, along with
the causes, treatment, and outcome of stroke in a large biracial
metropolitan population. It is estimated that 3,000 people in five area
counties in Ohio and Northern Kentucky will have a stroke each year.
Stroke is the country’s leading cause of adult disability. Local
researchers played a major role in the Food and Drug Administration’s
(FDA) approval of the first drug therapy shown to improve neurological
recovery and decrease disability in adults following acute ischemic
stroke. The drug, called tissue plasminogen activator (t-PA), helps
dissolve clots that block blood flow in the brain. The initial clinical
trial done at most area hospitals involved health professionals from
several disciplines and revealed that t-PA can significantly reduce the
brain damage caused by strokes if given within three hours of an attack.
Broderick says, "We’ve already shown that stroke is more prevalent than
previously thought. Now we will attempt to document every case of
stroke admitted at 18 Greater Cincinnati hospitals for a full year."
The stroke team will track the course of all stroke patients admitted
in 1999 to see if specific treatments were given in the first three
hours after the onset of the stroke, how the patients fared, and the
extent of genetic predisposition for stroke among different races of
The Greater Cincinnati/Northern Kentucky stroke team will also monitor
the public health department outpatient clinics, family practice
centers, 50 physician offices, and 25 nursing homes for stroke cases
that never get admitted to the hospital. "We are checking the pulse of
the community to see whether stroke is increasing or decreasing in
frequency as well as what stroke treatments are being used and which
ones work best," says Broderick.
Other UC members of the Greater Cincinnati/Northern Kentucky stroke
team working on this project include: Rashmi Kothari, MD, Arthur
Pancioli, MD, and Edward Jauch, MD, emergency medicine; Dan Kanter, MD,
and Dan Woo, MD, neurology; Thomas Tomsick, MD, neuroradiology; Rosie
Miller, RN (study coordinator), Laura Sauerbeck, RN, Janice Carrozella,
RN, Kathy Alwell, RN; statistical investigators Rakesh Shukla, PhD,
Jane Khoury, MS, Charlie Moomaw, PhD, and Shelia Salisbury, MS; Anil
Menon, PhD, and Yan Ru Su, PhD, molecular genetics and biochemistry.