With new funding from the United States Air Force, researchers at UCís Institute for Military Medicine will continue to investigate the best ways to treat injured soldiers in the theater of combat.
The two-year, $900,000 award provides funds for researchers to study the effects of hypobaric hypoxia on the bacterial colonization of complex musculoskeletal wounds.
Hypobaric hypoxia, or conditions of low air pressure and low oxygen content, describes the unique environment of air medical evacuation at high altitudes, says Timothy Pritts, MD, PhD, assistant professor of surgery at UC and study co-investigator.
Using an altitude chamber at the Brooks City-Base in San Antonio, UC and Air Force researchers will place bacteria inside an experimental wound model. They will then measure how low oxygen, low pressure and a combination of the two affect bacterial growth in the wound, before looking at possible ways to control the growth.
Pritts says initial measures could include putting the patient on oxygen to counteract the effect of altitude, or pressurization of the environment.
The next phase, says Alex Lentsch, PhD, director of UCís surgical research division and study co-principal investigator, will seek to determine the effect of a recent development in wound care, negative pressure wound therapy (NPWT), on the bacterial growth. In NPWT, a combination of a sponge attached to a suction source replaces packed gauze on the wound.
"Negative pressure wound therapy is a relatively modern evolution in wound care,Ē says Pritts. "It seems to work well to help wounds heal and to keep them clean and non-infected. It has come into very common use in the surgical world over the last eight years and itís now in use in the theater of combat with extremity wounds.Ē
But, he says, itís unknown whether the altitude and conditions of air medical evacuation change the therapyís efficacy.
"Itís really a question of viability in that environment,Ē says Lentsch. "Does the therapy work in that environment and does it have any effect on the wounds, other than the reason itís being used?Ē
Pritts says the collaboration between UC and the Air Force will allow residents from Daytonís Wright-Patterson Air Force Base to work on the research through the length of the grant. Past Air Force funding has allowed UC to study the effect of early evacuation on the bodyís inflammatory response and traumatic brain injury.
Col. Warren Dorlac, MD, associate professor of surgery and director of the Cincinnati Center for Sustainment and Readiness Skills (C-STARS) program, is also a co-principal investigator.