Patients who take medication for cancer often find themselves with a new problem when their treatment ends.
It's called "chemobrain," a common
consequence of chemotherapy that causes memory problems, confusion and
difficulty in concentrating.
Symptoms of chemobrain can also include
lack of focus, inability to organize daily activities, mental
confusion, memory loss and decreased mental clarity.
It's estimated that chemobrain occurs in
as many as 99 percent of breast and ovarian cancer patients receiving
chemotherapy or radiation treatments. Sixty-one percent of these
patients continue to experience fatigue and memory problems long after
their cancer treatment has stopped.
Now, researchers led by UC's Elyse Lower,
MD, report a possible new treatment for the problem using the drug
Dr. Lower, professor of
hematology/oncology at UC College of Medicine, recently described the
encouraging results of a 14-month, multicenter, Phase 2 study of d-MPH
to the annual meeting of the American Society of Clinical Oncology.
The 154 cancer survivors at 21 medical
centers showed significant reduction in fatigue and improvement in
memory when treated with dosages of 10 mg to 50 mg of d-MPH per day,
Dr. Lower said, when compared with a control group receiving a placebo.
All the patients, who had a median age of
53 years, had completed at least four cycles of chemotherapy at least
two months before the study began. Ninety percent of them were female
(76 percent with breast cancer and 14 percent with ovarian cancer), 79
percent white and 9 percent African-American.
"The study showed that up to 50 mg a day
of d-MPH is safe and effective for relieving chemobrain in adult cancer
patients," said Dr. Lower, "and it should be considered as a treatment."
One of the study participants, Marilyn Metz, had undergone radiation and chemotherapy in 2001 to treat breast cancer.
"I couldn't concentrate or focus long
enough to finish most tasks," she said. "I would start projects, but
couldn't concentrate, and often left them unfinished."
It got so bad that Metz found it difficult to talk to strangers on the phone.
"I wouldn't be able to think of a key
word in a sentence," she said. "I felt like the word was in the back of
my brain. I just couldn't drag it forward quickly enough."
Before receiving treatment for breast
cancer, Metz said, she had read about possible side effects such as
losing hair, but did not read anything about chemobrain.
After talking to Dr. Lower, she decided to participate in the study.
"What's the good of being successfully treated for breast cancer if your brain isn't working right?" she asked.
"I appreciate the chemotherapy and
radiation killing the cancer cells, and would take it again to continue
living," Metz added. "I'm even more thankful that new treatments are
being found to treat the fatigue and other side effects of chemobrain."
After treatment with d-MPH, she added, "I
can think more clearly and have more energy -- but I'm still able to
take naps in the afternoon, if I feel the need."
"This medication has really helped me," Metz said. "I feel like my brain capacity is back to normal."
All participants in this trial were
offered the real medication free after the trial had ended. Metz
participated in the control group and began using d-MPH following the
Coauthors of this presentation were from UC Medical Center and Beth Israel Cancer Center, New York, N.Y.