Watts Presents BMD Study Results
Published July 2003
Nelson B. Watts, MD, director of the UC Bone Health
Osteoporosis Center, presented results of his analysis on bone mineral
density and its reduction of non-vertebral fracture risk at the 85th
annual meeting of The Endocrine Society on June 19.
The analysis showed that increases in bone mineral
density (BMD) only accounted for six to 12 percent of the reduction in
non-vertebral fracture risk that resulted from osteoporosis treatment
over three years in postmenopausal women. Previously, analyses of
clinical trial data for three major osteoporosis therapies have shown
that increases in BMD account for only a fraction (<1/3) of the
total reduction in vertebral fracture risk. The new findings support
that this is also the case for fractures at nonvertebral sites, such as
the hip and wrist.
"The results uncerscore the importance of physicians
evaluating osteoporosis therapies based upon fracture reduction data,"
said Dr. Watts. "Many factors of bone quality are important for strong
bones, such as rate of bone turnover, bone micro-architecture, and
material properties of bone. Therefore, BMD should not be used to
compare fracture efficacy between osteoporosis therapies."