One in 3500 individuals worldwide has
neurofibromatosis type 1 (NF1), making it one of the most common of all
inherited disorders. NF1 patients are predisposed to the formation of
benign peripheral nerve tumors, neurofibromas. NF1 patients are also at
risk for learning disabilities, optic nerve tumors, skin
hyperpigmentation, bone deformities, and other problems. Neurofibromas,
present in nearly all NF1 patients, can cause disfigurement or
disability and can develop into malignant tumors that are lethal.
To understand how tumors form, and
ultimately to halt their formation, this new consortium project brings
together seven groups of investigators from around the world to compare
and contrast mouse and human NF1 tumor data.