Gout Gene Next Target?
Published August 2004
UC researchers have found evidence of a genetic cause for gout, a
disease that leads to inflammation, swelling and pain in the joints.
The scientists, led by Ranajit Chakraborty, PhD, director of the Center
for Genome Information in UC's Department of Environmental Health,
identified a susceptibility region for the disease on chromosome 4,
strong evidence that further research will pinpoint specific
Caused by a buildup of uric acid, gout is common among men over 55.
Although not a major killer, it's costly in terms of treatment and lost
The findings will appear in the September 2004 issue of the American
Journal of Human Genetics (AJHG) and are available online at
Dr. Chakraborty and one of his past graduate students, Li Shu-Chuan
Cheng, studied 154 Taiwanese aborigines from 21 multigenerational
families, each containing multiple individuals with gout. Their
conclusions, they say, can be applied to other populations.
The researchers will now use their data to examine several genes on
chromosome 4 for mutations responsible for gout and other complex
Dr. Chakraborty, Robert A. Kehoe Professor at UC, was part of an
international team that in April published more than 21,000 gene
transcripts of the human genome.